You will be hard pressed to avoid spiders in their entirety in Bali or anywhere in SE Asia. Spiders ranging from tiny to fairly large live throughout the region, but that doesn't mean they will be jumping out at you around every corner.
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Venomous spiders, in general, will not bite you unless they feel threatened or provoked. In Indonesia, most spider bites are not considered to be harmful to humans. Very few spider bites result in victims requiring urgent medical attention or treatment.
Mosquito borne diseases found in Bali include dengue fever, chikungunya and zika virus. Whilst there are vaccines for Japanese encephalitis, mosquito avoidance is the only way to prevent many of these diseases.
The town is known for its laid-back atmosphere and friendly locals, and the crime rate is low. However, it is always important to take the usual safety precautions, such as avoiding walking alone at night, not carrying large amounts of cash, and being aware of your surroundings.