Passengers must be offered oxygen at 15,000 feet. If you are flying at a pressure altitude of 12,500 feet to 13,999 feet, once you hit the thirty-minute mark, you need to put on that oxygen.
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For best protection, you are encouraged to use supplemental oxygen above 10,000 feet MSL. At night, because vision is particularly sensitive to diminished oxygen, a prudent rule is to use supplemental oxygen when flying above 6,000 feet MSL. So, when you fly at high altitudes, supplemental oxygen is the only solution.
Values >95% on room air suggest that inflight hypoxemia is unlikely and that further evaluation is likely not necessary. Patients with saturations <92% on room air at rest should receive supplemental oxygen inflight, because they are at high risk of hypoxemia at altitude.
In aeronautics, hypoxia typically results from a decompression or lack of pressurisation of the aircraft cabin. Hypoxia occurs within a few minutes if the cabin pressure altitude rises to between 5,000-6,000 m (about 16,000 - 20,000 ft).
The only oxygen equipment allowed on an airplane is the portable oxygen concentrator (POC). If you need oxygen in flight, you must take a portable oxygen concentrator with you, and , you must let your airline know ahead of time. They may require a doctor's letter to verify the need for the POC on the plane.
The air on a plane contains less oxygen than the air we normally breathe in.This leads to lower levels of oxygen in the blood. If you do not have a lung condition, the drop in oxygen is not enough that you would feel the difference.