Most information about blood clots and long-distance travel comes from information that has been gathered about air travel. However, anyone traveling more than four hours, whether by air, car, bus, or train, can be at risk for blood clots.
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Blood clots can sometimes form in your legs during air travel because you are immobile for long periods of time, often sitting in cramped spaces with little leg room. The clinical term for this type of blood clot is deep vein thrombosis (DVT).
Most people don't need to worry much about clots on short flights. But if you're already at risk for clots and you plan to take a plane trip that's longer than 6 hours, you can do a few things to avoid them. Get up and walk around every 2 to 3 hours.
Traveling longer than 8 hours, whether by plane, car, bus, or train, can increase risks for life-threatening blood clot. The risk of a blood clot is about 3-times higher for people traveling on long-distance flights.
Remember that anything over 6 hours flying time is considered long haul, but flights of longer than 10 hours are not uncommon either. One important thing to remember is to keep your seat belt fastened at all times in case of unexpected turbulence.
One study estimates that 1 in 4,600 travelers will have a blood clot within 4 weeks of a long flight. According to Dr. Kahn, “the actual risk of a travel-related blood clot is quite small, and the average traveler doesn't need to worry about it.
There has been considerable attention focused recently on the risk of deep venous thrombosis (DVT) associated with air travel. Despite the lack of evidence among air travelers, a single dose of aspirin has been widely recommended as a means of preventing such thrombosis.