Yes, a plane can technically fly without a bathroom, but it is rarely done on commercial passenger flights due to passenger comfort and FAA/DOT regulations. For small, single-aisle aircraft with fewer than 60 seats, a bathroom is not legally required for short-duration flights. However, in 2026, for larger commercial aircraft (typically 125+ seats), the Department of Transportation has implemented strict accessibility rules requiring at least one accessible lavatory. Military aircraft, such as fighter jets, famously fly without bathrooms; pilots on long missions utilize "piddle packs"—bags containing water-absorbent powder that turns liquid into a gel—to relieve themselves while maintaining control of the aircraft. For general aviation and private flights, "bathroom-less" travel is common for short hops in small Cessnas or Pipers. On commercial airlines, if all lavatories on an aircraft are inoperative (broken), the flight is generally grounded or diverted, as it would be considered a "passenger health and safety" issue to operate a multi-hour flight without functional facilities.