Changes in atmospheric pressure are related to a higher incidence of spontaneous primary pneumothorax. Atmospheric pressure changes from day to day are usually small. However, during flying or diving significant changes in pressure will occur.
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Low air pressure during air travel also decreases the amount of oxygen in the air. This effect is modest and generally not noticeable for healthy travelers. For patients with significant lung disease, a small decrease in available oxygen can cause significant symptoms, especially with exercise.
Most people with a lung condition can travel safely on planes, but you should talk to your doctor before you make any plans. You may need a fitness-to-fly (hypoxic challenge) test to confirm whether you need in-flight oxygen.
Severe episodes (massive embolism) present with collapse, severe breathlessness, and central chest pain. Symptoms of VTE commonly develop during or immediately after a flight, often while still in the airport.
The cramped conditions and long periods of being less active on a flight can cause pain, stiffness or swelling of your legs. Being less active can lead to slow blood flow in your veins which increases your risk of developing a blood clot, known as deep vein thrombosis (DVT). DVTs most commonly form in the legs.