Yes, you can generally cancel a single ticket on a multi-person airline reservation, but the process usually requires an extra step called a "PNR Split." When you book multiple people together, you share a single Passenger Name Record (the 6-digit booking code). To cancel just one person, the airline (or your travel agent) must "split" that passenger off into their own unique booking code. Once they have their own code, their individual ticket can be cancelled or changed without affecting the rest of the group. In 2026, many major airline apps and websites (like Delta or IndiGo) allow you to do this yourself through the "Manage Booking" portal. However, if you are on a "Basic Economy" or non-refundable fare, you might not get your money back; instead, you may receive a travel credit in that specific passenger's name. It is always important to check the "fare rules" of your original booking, as some highly restrictive group fares may not allow partial cancellations without significant fees or the loss of the entire group's discounted rate.