No, you cannot travel all the way to Prague using only the 49-Euro Ticket (now officially priced at €63 as of January 2026). The "Deutschlandticket" is valid only for local and regional transport within Germany. While it allows you to reach certain "border stations" in neighboring countries—such as Salzburg in Austria or Basel in Switzerland—it does not extend into the heart of the Czech Republic. To get to Prague, you can use your D-Ticket to travel as far as the German border (usually Dresden or Schöna), but you must then purchase a separate ticket from the Czech railway (České dráhy) for the remainder of the journey. For 2026 travelers, the most cost-effective way is to combine your regional D-Ticket with a "Sparpreis" (saver fare) ticket from Deutsche Bahn for the international leg.