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Can I sedate my cat for a flight?

Sedatives can interfere with regular breathing and other bodily responses, and pets may react differently and unexpectedly to medications when they are in the air. In fact, most airlines will not fly a sedated pet, as over-sedation can be a cause of animal death during air transport.



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Buprenorphine (brand names Buprenex®, Simbadol® ), gabapentin (brand name Neurontin®), and alprazolam (brand names: Xanax®, Niravam®) are examples of medications that are sometimes prescribed by veterinarians to reduce the anxiety that some cats experience when traveling.

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Strategies to de-stress feline flights include:
  • A Thundershirt® which swaddles the cats much like swaddling an infant and can reduce anxiety.
  • Feliway® pheromone wipes and spray can be used in the carrier prior to flying can help lower anxiety.
  • A pheromone calming collar can help to lower anxiety.


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Dramamine, Bonine, and Antivert are over-the-counter human antihistamines that can be purchased in many stores, and even some gas stations. Not only will they stop motion sickness, but they can also sedate your pup to help ease their anxiety while in the car. Benadryl is another human antihistamine that does it all!

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Benadryl dosage for cats However, recommended doses of Benadryl for cats are typically 1 mg per 1 pound, to be given every 8-12 hours as needed. Consult your vet and use this interactive calculator to determine how much Benadryl you should give your cat.

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Help your cat see the carrier as a safe space,” she says. “Leave it out all the time, and place a favorite blanket and treats in it, or even feed your cat meals in the carrier. During the flight, that familiar-smelling blanket will provide them with some comfort.”

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Adult dogs and cats easily make it through the night without having to relieve themselves, so your pet should also be OK on most very long flights. Regardless, you'll have to line their carrier with something absorbent - a Dry Fur pad works nicely under your pet's own crate pad or thin blanket.

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Confine your pet Use a pet restraint, preferably a hard-shelled crate, to keep your cat contained in the car. If you're flying to your new home, follow your airline's recommendations for the proper crate or carrier. Make sure the carrier is secured and level in a seat with a vent pointing toward it for ventilation.

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If you must take your nervous pup or pussycat on an airplane, follow this expert advice to make the experience run smoother for you and your pet.
  1. Know Signs of Distress. ...
  2. Travel With Your Puppy. ...
  3. Bring a Familiar Comfort Object. ...
  4. Perform Crate or Carrier Training. ...
  5. Swaddle Your Fur Baby. ...
  6. Try Aromatherapy.
  7. Remain Calm.


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