No, you generally cannot skip the first leg of a flight itinerary without severe consequences in 2026. According to the "No-Show" policies used by almost all major airlines (including United, Delta, and Lufthansa), if you miss the first segment of a ticket, the airline's computer system automatically cancels all remaining segments, including your return flights, with no refund. This is done to prevent "hidden city ticketing" or "skiplagging," where passengers book cheaper multi-city flights but only intend to use a portion. While you might save money upfront, the airline sees the unused first leg as a contract violation. If you must skip a leg due to an emergency, you must contact the airline before the first flight departs to have them manually "protect" the rest of your itinerary, which usually involves a significant re-faring fee that negates any original savings.