Yes, you can use your CPAP machine without water in the humidifier chamber, but you must take specific steps to protect the device. Most modern CPAP machines have a "Humidifier" or "Humidity Level" setting; if you aren't using water, you should navigate to the settings menu and turn the humidity to "Off" or "0." This prevents the heating plate from warming up, which can cause a burning smell or damage the empty plastic water tub. Using a CPAP "dry" is often more convenient for travel as it eliminates the need to carry distilled water. However, many users find that breathing dry air leads to a very dry mouth, throat irritation, or "rainout" (condensation) issues if the room is cold. If you plan to go waterless frequently, you might consider a "Humidification Bypass" or a "side cover" that replaces the water tub entirely, making the machine smaller and more streamlined. For short trips, using the machine without water is a safe and common practice.