Mamajuana, the traditional Dominican drink made of rum, red wine, honey, and a mixture of barks and herbs, can indeed make you sick if consumed improperly or sourced from unreputable vendors. In 2026, the primary risk comes from bacterial contamination in "homemade" versions or the use of specific botanicals that may act as potent diuretics or stimulants. Because the ingredients are often left to macerate in a bottle for long periods, improper hygiene during the initial bottling can lead to digestive upset or "traveler's diarrhea." Additionally, the high alcohol content and the presence of natural compounds that supposedly act as aphrodisiacs can cause heart palpitations, nausea, or dizziness in those sensitive to stimulants. Travelers are advised to purchase professionally bottled versions from established brands rather than open-market jugs. As with any potent herbal infusion, moderation is key, and individuals with heart conditions or those on medication should exercise extreme caution due to potential herb-drug interactions.