Yes, nail polish and nail polish remover fumes can absolutely set off modern fire alarms, particularly those that use photoelectric sensors. In 2026, most household and hotel smoke detectors work by scattering light; when dense chemical vapors from lacquer or acetone (the main ingredient in remover) drift into the sensor chamber, the device "mistakes" these particles for smoke and triggers the alarm. This is especially common in small, poorly ventilated spaces like hotel bathrooms. Beyond just triggering the alarm, these fumes can actually damage the sensor over time, with manufacturers noting that high concentrations of aerosols and paint fumes can cause the device to "fail safe" and stop functioning correctly. For 2026 travelers, the "safe bet" is to paint your nails near an open window or in a well-ventilated area to prevent a loud, embarrassing false alarm and a potential "service fee" from hotel security.