The natural history of food allergy indicates that such allergy can be outgrown and therefore shows that it is possible to acquire tolerance after sensitization has occurred. Unfortunately, natural tolerance is infrequent for antigens such as peanut, tree nuts, fish, or shellfish.

In 2026, the medical consensus is that while a permanent "cure" remains elusive for most, many individuals can significantly increase their tolerance through Oral Immunotherapy (OIT). This process, often referred to as desensitization rather than true immunity, involves consuming tiny, medically supervised amounts of the allergen (like peanut protein) to retrain the immune system. Recent 2026 studies have shown that even "low-dose" OIT (as little as 30mg) can protect children from life-threatening reactions caused by accidental exposure. However, this "immunity" is typically maintenance-dependent; if the individual stops consuming the daily maintenance dose, the allergic sensitivity often returns. It is a high-value medical intervention that transforms a "deadly" allergy into a manageable condition, though it requires lifelong commitment and should never be attempted without the direct supervision of a board-certified allergist.