You can initiate a chargeback for a non-refundable hotel room, but winning is difficult unless you have a legally valid reason. Simply "changing your mind" or having a personal emergency (like a family illness) is generally not enough, as you explicitly agreed to the "non-refundable" terms at purchase. However, you have a strong case if the hotel fails to provide the service—for example, if they are closed, overbooked, or the room is significantly different from what was advertised (e.g., no running water or power). Another valid reason is "clerical error," such as being billed twice. In 2026, most banks require you to try resolving the issue with the hotel first. To avoid this risk, it is better to purchase travel insurance with "Cancel for Any Reason" (CFAR) coverage, which protects your investment even when the hotel’s own policy is strictly non-refundable.