Yes, you can absolutely cruise from Southampton to America, a route famously known as the Transatlantic Crossing. The most iconic way to do this in 2026 is aboard the Cunard Line's Queen Mary 2, which is the only true "ocean liner" specifically built to handle the rough waters of the North Atlantic. These voyages typically take 7 nights to reach New York City (Brooklyn Cruise Terminal). Unlike a standard cruise with multiple port stops, a crossing is focused on the onboard experience and the tradition of "slow travel." Other major lines like Royal Caribbean, Celebrity, and Norwegian also offer these routes, but they are usually "Repositioning Cruises" that occur seasonally in the spring (moving to Europe) or autumn (returning to the Americas). These repositioning voyages often last 12 to 14 days and may include stops in the Azores or Bermuda, offering a more leisurely pace and often a significantly lower price point than a standard week-long Caribbean or Mediterranean itinerary.