You can absolutely dispute a charge or a service issue with Expedia, though the process often requires persistence since Expedia acts as a third-party intermediary between you and the actual service provider (airline, hotel, or car rental). The first step is to use their "Customer Support" portal or virtual agent to initiate a formal complaint. If you were charged for a "non-refundable" booking due to an emergency or a provider's error, you must often get written authorization from the hotel or airline first, as Expedia generally cannot override their specific policies without consent. If Expedia's internal resolution fails, you can escalate the matter through your credit card company by filing a formal "chargeback" for services not rendered or incorrect billing. However, be aware that filing a chargeback can sometimes lead to being blacklisted from future bookings on Expedia-owned platforms. For smaller claims, some travelers have found success using the Better Business Bureau (BBB) or small claims court. The key to a successful dispute is maintaining a meticulous paper trail of all confirmations, cancellation emails, and chat transcripts to prove that the terms of your contract were not met.