The simplest way to get from Italy to Switzerland is by train although driving is fine too. I bought a $23 train ticket from raileurope.com to go from Lake Como to Lugano and the ride was a breeze. While my ride took exactly 39 minuets, the quickest route is 25 minutes.

Yes, a day trip to Switzerland from Lake Como is incredibly easy and highly recommended due to the proximity of the border. The most popular destination is Lugano, which is only about 40 to 60 minutes away by train or car from the town of Como. Another spectacular option is taking the Bernina Express; you can drive or take a train to Tirano (Italy) and board the panoramic Swiss train that climbs through the Alps to St. Moritz. This journey is a UNESCO World Heritage experience and can be done in a single long day. If you prefer something closer, the Swiss town of Mendrisio is famous for its "FoxTown" luxury outlet mall. Just remember to bring your passport (though the border is often open) and be prepared for a significant jump in prices, as Switzerland is much more expensive than the Italian side of the lake.