You generally cannot perform a "split payment" using two different credit cards directly on most major airline websites, as their checkout systems are typically designed to process only one primary form of payment per transaction. However, there are several workarounds to achieve a similar result. Many travelers use Online Travel Agencies (OTAs) like Alternative Airlines or Air Trip Masters, which specifically offer a "split payment" feature at checkout. Another common method is to use an airline gift card to cover a portion of the cost and then pay the remaining balance with a credit card; most major carriers like Delta, American, and United allow this "Mixed Payment" method. Additionally, some airlines offer "Miles + Cash" options, allowing you to use loyalty points to reduce the fare and then pay the rest with a card. For group travel, some platforms allow you to "Hold" a fare and then have each passenger pay their portion individually through a shared link. If you specifically need to use two credit cards for a single ticket on a carrier that doesn't support it online, your best bet is often to call the airline's reservation desk directly, where an agent may be able to manually process the split transaction for a small fee.