For most visitors, the answer is a firm no, as the historic centre of Florence is a strictly regulated ZTL (Zona a Traffico Limitato). This means that only residents, public transport, and vehicles with special permits are allowed to drive within the heart of the city during certain hours. If you drive a rental car into the ZTL without a permit, you will be automatically photographed by enforcement cameras and issued a heavy fine (often €100 or more) per entry. If your hotel is located inside the ZTL, you can usually drive to it only if the hotel staff registers your license plate with the local police upon your arrival to "whitelist" your entry for that specific window. However, the streets are extremely narrow, crowded with pedestrians, and parking is prohibitively expensive. In 2026, the best strategy for visitors is to park their car in a large "scambiatore" (commuter) lot on the outskirts of the city, such as Villa Costanza (located directly on the A1 highway), and take the modern T1 tram into the city centre. This avoids the stress of Italian traffic and the high probability of receiving a "surprise" ticket in the mail months later.