Generally, yes, you can fly with high cholesterol as the condition itself does not pose an immediate risk during air travel. However, the primary concern for travelers with high cholesterol is the increased risk of Deep Vein Thrombosis (DVT) or cardiovascular events due to long periods of inactivity in a pressurized cabin. Medical experts recommend that such passengers stay hydrated, avoid excessive alcohol, and wear compression stockings if they have other circulatory issues. It is crucial to walk around the cabin every hour or perform "seat exercises" like ankle circles to keep blood flowing. If you are taking medication like statins, ensure you carry them in your hand luggage with a copy of your prescription. While high cholesterol isn't a "no-fly" condition, if it has led to more serious issues like unstable angina or a recent heart attack, you must consult a doctor for a formal "fit to fly" assessment before boarding.