Like cars, boats and planes, riding on a train can cause motion sickness too.
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Motion sickness happens when the movement you see is different from what your inner ear senses. This can cause dizziness, nausea, and vomiting. You can get motion sick in a car, or on a train, airplane, boat, or amusement park ride.
Because motion sickness is caused by mixed signals of what you see and hear, it's best to sit where there is less movement during the journey. Typically, the best seats for this are in the middle, as you are more likely to remain still there as the engine's vibrations and bumps in the road are felt less.
It's a very bumpy ride and many times the train must change tracks because freight trains take precedence. The freight train tracks are not smooth at all. Sleeping car rooms are expensive and very small. It's hard to fit one suitcase in your room.
Drink plenty of water. Dry crackers and carbonated sodas (such as ginger ale) help some people avoid nausea. People who tend to have motion sickness may want to eat small, frequent meals.
Amtrak passenger cars these days, are for the most part smooth riding indeed. I would have to classify the Superliner cars as the best-riding railroad passenger cars I've ever ridden, and that includes time spent in the 1980's riding DB.
Trains are statistically much safer than driving. In 2020, the Bureau of Transportation Statistics recorded 40,867 total deaths from travel, including in planes, in cars on highways and on trains.