No, you generally cannot skip the first leg of a connecting flight in 2026 without the airline automatically cancelling the remainder of your entire itinerary. Most airlines operate under a "sequential use" policy in their contract of carriage; if you do not show up for the first flight (City A to City B), the system marks you as a "no-show" and voids your onward ticket to City C, as well as any return flights. This is to prevent "hidden city ticketing," a practice used to find cheaper fares. If you have a genuine emergency and must miss the first leg, you must contact the airline before the flight departs to see if they can rebook or protect the rest of your trip, though this often involves a heavy fare difference fee. The only safe way to skip a segment is if it is the final leg of a one-way trip (and you have only carry-on bags), as the airline has nothing left to cancel—though doing this frequently can still lead to a ban from the airline or loss of frequent flyer miles.