Generally, yes, you can sleep in compression socks to help manage Restless Leg Syndrome (RLS), but there are important caveats. Many RLS sufferers find that the gentle, consistent pressure helps "quiet" the nervous system and reduces the "pins and needles" sensation, potentially improving sleep quality by up to 50%. However, most medical professionals recommend that you use graduated compression socks with a lower pressure level (15-20 mmHg) for sleeping, as your blood doesn't have to fight gravity as hard when you are horizontal. It is crucial to ensure the socks fit perfectly; if they are too tight or bunch up at the ankle or behind the knee, they can actually restrict circulation or cause skin irritation. If you have underlying conditions like diabetes or peripheral artery disease, you should consult a doctor before wearing them overnight. For many, wearing them for a few hours before bed provides the necessary relief without needing to wear them all night.