You cannot take a direct boat from Rome to the Amalfi Coast because Rome is located inland on the Tiber River, while the Amalfi Coast is over 170 miles away on the southern Mediterranean. However, in 2026, the most popular and scenic way to achieve this is the "Train-and-Ferry" combination. You take a high-speed Frecciarossa train from Rome Termini to Salerno (about 1.5 to 2 hours), and from there, you walk five minutes to the pier to catch a ferry (Travelmar or NLG) directly to Amalfi or Positano. The ferry ride takes about 35 minutes and offers breathtaking views of the coastline that you cannot see from the road. Some luxury tour operators in 2026 also offer private "Land-and-Sea" transfers where they drive you to the port of Piano di Sorrento for a private boat charter. While a direct boat from Rome's nearest port (Civitavecchia) is technically possible via private yacht, it would take nearly a full day and cost thousands of dollars, making the Salerno-ferry link the preferred choice for 99% of travelers.