Yes, you can tour the main highlights of Brussels in a single day because the city center is remarkably compact and walkable. A well-planned 2026 itinerary would start at the Grand Place, widely considered one of the most beautiful town squares in the world, before visiting the nearby Manneken Pis statue. From there, you can walk to the Royal Quarter to see the Royal Palace and the Mont des Arts for a panoramic view of the city. After a lunch of traditional Belgian frites or waffles, you can take a short 20-minute metro ride (Line 6) to the Heysel district to see the Atomium, the iconic retro-futurist landmark built for the 1958 World's Fair. While you won't have time for deep dives into every museum (like the Magritte Museum or the Comic Strip Center), a one-day trip is perfectly sufficient to experience the "vibe" of the city, see the major architecture, and sample the world-famous Belgian chocolate and beer before heading to your next destination.