Yes, a particularly notorious incident occurred in September 2023 on Delta Air Lines Flight 194 from Atlanta to Barcelona. Approximately two hours into the trans-Atlantic journey, the pilot was forced to turn the Airbus A350 around and return to Atlanta because a passenger suffered a bout of "severe diarrhea" that affected the entire length of the aircraft's center aisle. The pilot officially described the situation to air traffic control as a "biohazard issue," noting that the waste had spread throughout the cabin, making it impossible to continue the flight safely. Upon returning to Atlanta, the aircraft underwent an intensive eight-hour deep cleaning, and the carpet was reportedly replaced in several sections. The passengers were eventually put on a different aircraft (or the same one after it was sanitized) to finish their journey to Spain. This event went viral globally, serving as a visceral reminder of the "biohazard" protocols airlines must follow for the safety and comfort of all passengers.