Yes, cruises frequently depart at night, though the most common departure window is between 4:00 PM and 7:00 PM. This timing is strategic for several reasons. First, it allows the ship to clear the harbor and reach open waters just as the sun sets, providing a scenic "Sail Away" party for passengers. Second, departing in the late afternoon or evening gives the ship enough time to travel to the next port of call by early the following morning. In some specific itineraries, such as those in the Mediterranean or the Caribbean, a ship might have a "Late Night Stay" where it doesn't depart until 10:00 PM or even midnight, allowing guests to enjoy the local nightlife, dinner on shore, or evening excursions. For "repositioning" cruises or short "cruises to nowhere," nighttime departures are also common to maximize the use of the ship's casinos and shops, which can only open when the vessel is in international waters. Always check your specific "Boarding Pass" for the "All Aboard" time, which is usually 90 minutes before the scheduled night departure.