Sheets are usually changed between guests, and sometimes state law requires it, but there's no guarantee that they will be. As for bedspreads, forget it.
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The quick answer is that a small blood stain on bed sheets is fairly common and you likely won't be charged anything extra. Hotels have procedures for removing blood and bodily fluid stains, usually by bleaching the linens. However, you may want to alert housekeeping to ensure thorough cleaning.
But beware of stealing sheets, artwork, electronics, or those incredibly comfy robes. While you probably won't get arrested, it's likely that the hotel will charge you for the item. Some will even put you on a “no stay” list, which will prevent you from booking a room there again.
Typically, hotels wash their bedding once every week including various kinds of comforters, sheets, and pillows. However, they often swap out the pillowcases and linens between the guests. It's a common practice that the hotel comforters are rarely automatically changed – unless a guest requests it.
Glassware, linen and the TV remoteTypically, they don't get cleaned between guests and become a breeding ground for bacteria. Use the pillows from the closet; they're more likely to be freshly washed than the ones on the bed.
For the sleeping area, check the underside of the pillows to see if they've simply been flipped, and inspect the sheets properly – any remaining wrinkles are a sign they have not been cleaned, and any brown 'spots' could be bed bugs – which is incredibly serious, and you should leave immediately.
While no hotel room can be 100% free of germs, most nice hotels are doing everything they can to ensure your room is sanitary and ready for each guest. Taking a few precautions puts you ahead of most travelers, and you wouldn't even have to bring your own sheets to take advantage of that.
Sheets are usually changed between guests, and sometimes state law requires it, but there's no guarantee that they will be. As for bedspreads, forget it. As countless hidden-camera investigative TV programs have confirmed, they aren't washed regularly.
Request new linens, pillows, or blankets: When you arrive, you can request new linens or pillows, even blankets, from the hotel before you settle in. In upscale hotels, sheets are typically the cleanest thing in the room, but freshly washed pillows could help. Bring your own sheet set: Extreme? Maybe.
I've Done This. The next time you're staying at a hotel, when done with your towel, leave it hanging or on the sink. It's one less towel the staff need to pick up from the floor. It's a small act but can make a difference.
If you take something from your hotel room, you can expect an extra charge on your bill. Robes and towels are so commonly stolen that many hotels now list the charge right on the hanger; they will automatically bill the credit card they have on file for the extra cost of replacing these items.