The CDC and WHO recommend the following vaccinations for the Dominican Republic: hepatitis A, hepatitis B, yellow fever, typhoid, cholera, rabies, meningitis, polio, measles, mumps and rubella (MMR), Tdap (tetanus, diphtheria and pertussis), chickenpox, shingles, pneumonia and influenza. Shot lasts 2 years.

While there are no mandatory vaccinations required by the Dominican government for entry from most countries (unless you are traveling from a region with a high risk of Yellow Fever), health organizations like the CDC and WHO strongly recommend several "injections" or vaccinations for travelers to Punta Cana. At a minimum, you should ensure your routine vaccinations, such as Measles-Mumps-Rubella (MMR), Diphtheria-Tetanus-Pertussis, Varicella (chickenpox), and Polio, are up to date. For most travelers, Hepatitis A and Typhoid vaccines are highly recommended because they can be contracted through contaminated food or water, regardless of where you are staying. If you plan on engaging in outdoor activities, visiting rural areas, or staying for an extended period, you might also consider vaccinations for Hepatitis B and Rabies. Malaria is generally a low risk in Punta Cana, but mosquito-borne illnesses like Dengue and Zika are present, so using high-quality repellent is advised. It is best to consult a travel clinic at least 4–6 weeks before your departure to receive any necessary boosters.