No, for both the TSA (USA) and CATSA (Canada) in 2026, medications do not have to be placed in your 1-liter clear plastic bag. While liquids, gels, and aerosols for general use are restricted by the 3-1-1 rule, medically necessary liquids are exempt. You are allowed to carry prescription and over-the-counter liquid medications in quantities larger than 100ml. However, you must declare them to the screening officer at the checkpoint. It is highly recommended to keep them in their original packaging with the prescription label visible to speed up the manual inspection. Solid tablets and pills have no volume restrictions and can remain in your carry-on without being declared, though keeping them in a separate pouch for organization is a smart travel habit to avoid delays during secondary screenings.