While there are no "mandatory" vaccinations required to enter the Dominican Republic from the U.S. or Europe, both the CDC and WHO strongly recommend several shots for a safe trip to Punta Cana in 2026. At a minimum, you should be up-to-date on Routine Vaccines like MMR, Tetanus (Tdap), and Polio. Because food and water-borne illnesses can occur even in all-inclusive resorts, Hepatitis A and Typhoid vaccines are highly recommended for most travelers. Hepatitis B is also suggested if you might have medical procedures or new piercings/tattoos while abroad. Interestingly, Yellow Fever vaccination is only required if you are traveling from a country with a high risk of transmission (such as parts of South America or Africa). While not a "shot," travelers are also advised to use high-quality insect repellent to prevent mosquito-borne illnesses like Zika and Dengue, which are present in the region. Always check with a travel clinic at least 4–6 weeks before your trip to ensure your "traveler's kit" is complete and your immunity is fully active.