Yes, American Express provides significant benefits and indirect discounts on rental cars, primarily through their premium card offerings like the Platinum Card and the Gold Card. While they don't always offer a "flat percentage" discount on the base rate like a coupon, they provide elite status and specialized "CID" (Corporate ID) codes that unlock preferred pricing. For instance, Platinum cardholders receive complimentary elite status with Hertz (President's Circle), Avis (Preferred Plus), and National (Emerald Club Executive). These statuses often include "rent a midsize, drive a luxury" upgrades, which represent a massive value. Furthermore, using an Amex card often grants you access to "The Car Rental Program," which can include up to 25% off base rates and waived additional driver fees with specific partners. One of the most valuable "hidden" benefits is the Premium Car Rental Protection; for a small flat fee per rental (around $12–$25), Amex provides primary collision damage coverage, allowing you to decline the expensive $30/day insurance offered at the rental counter. This can save a traveler hundreds of dollars on a week-long trip, making the American Express ecosystem one of the most powerful tools for frequent car renters.