As of the 2026–2027 cruise season, Royal Caribbean does not have a year-round homeport in San Francisco. While they occasionally use San Francisco as a "port of call" on Pacific Coastal or repositioning cruises (often moving ships between Alaska and Australia), their primary West Coast hubs remain Los Angeles (San Pedro) and Seattle. In 2026, the Quantum of the Seas and Navigator of the Seas are the main vessels serving the California market, primarily operating out of Los Angeles for Mexican Riviera and Ensenada itineraries. If you are looking to depart specifically from San Francisco, you would typically look at Princess Cruises or Carnival, which maintain a more consistent presence at Pier 27. Royal Caribbean fans in Northern Italy or the Bay Area usually find it more convenient to take a quick flight to LAX or Seattle to catch the larger "Quantum-class" ships that the line is famous for.