Yes, the venomous Boomslang snake plays a central role in several key scenes in the 2022 film Bullet Train. While the snake is initially stolen by the assassin known as The Hornet (Zazie Beetz) to use its venom as a weapon, it eventually acts independently. In the film's climactic moments, the protagonist, Ladybug (Brad Pitt), is bitten on the hand by the snake while reaching under a table for a purse. This leads to a frantic sequence where he must administer an antidote to himself. Furthermore, the character The Hornet is ironically killed by her own snake venom when Ladybug manages to stab her with her own poison-filled syringe. The movie portrays the venom as a fast-acting toxin that causes victims to bleed from every orifice—a stylized exaggeration of the real-life Boomslang's hemotoxic venom, which is actually much slower-acting. Despite the biological inaccuracies, the snake serves as both a "MacGuffin" and a comedic element, ultimately being one of the few "survivors" to escape the train wreckage at the end of the film.