Yes, Thrifty Car Rental accepts American Express as a valid form of payment for vehicle rentals globally. In addition to American Express, they accept other major credit cards such as MasterCard, Visa, Diners Club, and Discover. When renting, the card must be in the primary driver's name and have sufficient available credit for both the estimated rental charges and a standard authorization hold, which is typically around $200 for credit cards. While Thrifty also accepts debit cards at many locations, using an American Express credit card is often smoother as it generally bypasses the more stringent requirements sometimes applied to debit users, such as proof of a return travel ticket or additional identity verification. Furthermore, many American Express cards provide secondary rental car insurance, though you should verify your specific card's benefits before declining Thrifty's optional Loss Damage Waiver (LDW).