They do inspect bags at security and can ask to look inside any bag you have but in several decades of travel I've never had security anywhere ask to completely empty a bag. In my experience if they see something suspicious on the x-ray typically they'll just dig around in it. They won't take everything out.

Yes, TSA will check your purse as part of the standard security screening process at all U.S. airports. When you reach the checkpoint, you must place your purse (and any other personal items) in a bin to go through the X-ray scanner. The officers are looking for prohibited items such as liquids over 3.4oz, weapons, or large electronics. In 2026, many airports use advanced 3D CT scanners that allow you to leave everything inside your bag, but in older lanes, you may still need to remove your tablet or e-reader. If the X-ray reveals something suspicious or "unidentifiable," an officer will perform a manual bag search, where they will open your purse and inspect the contents in your presence. To speed up the process, ensure that any "loose" liquids are in a clear, quart-sized bag and that your purse isn't so cluttered that the X-ray cannot clearly see through the different layers of your belongings.