While the TSA does not "systematically" open every packing cube, they certainly can and will if your bag is flagged for a manual search. In 2026, many airports have upgraded to advanced CT (Computed Tomography) scanners that create 3D images of your luggage, allowing officers to see "through" cubes without opening them. However, if the scanner detects an "opaque" mass or a prohibited item (like a forgotten bottle of water or large electronics) inside a cube, the officer will open your suitcase and un-zip the specific cube to inspect the contents. Using mesh or clear-topped packing cubes is a "pro-traveler" move, as it allows security officers to quickly verify the contents without rummaging through your neatly folded clothes. If your bag is searched, the TSA is supposed to leave a "Notice of Baggage Inspection" card inside. Ultimately, cubes don't prevent searches, but they do make it much faster for you to repack your bag if an inspection occurs.