Visiting Victoria Falls requires vaccinations against Yellow Fever, Hepatitis A and B, and Tetanus. You will also need to take anti-Malaria medication, especially important when you are travelling to the falls during wet season as mosquitoes are at their highest levels.

Mosquitoes can be a significant presence in Victoria Falls, particularly because the area is a high-risk malaria zone. The intensity of the mosquito population fluctuates with the seasons; they are most prevalent during the wet summer months (November to April) when the heat and standing water from the Zambezi River provide ideal breeding conditions. During the dry winter (May to August), the population drops significantly, but they never entirely disappear. Because the falls create a constant "rain" of mist, the surrounding rainforest stays humid year-round, which attracts insects. Visitors are strongly advised to take malaria prophylaxis after consulting a doctor. To minimize bites, you should wear long-sleeved shirts and trousers during the "peak hours" of dawn and dusk, apply insect repellent containing DEET, and utilize the mosquito nets provided by most hotels. While they can be a nuisance, following these standard precautions usually allows travelers to enjoy the natural wonder without major issues.