How can I sedate my cat at home for travel?

A pheromone calming collar can help reduce anxiety. Medication prescribed by your veterinarian: Buprenorphine (brand names: Buprenex®, Simbadol®), gabapentin (brand name Neurontin®), and alprazolam (brand names Xanax® and Niravam®) are sometimes used to reduce travel anxiety.



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As in humans, Benadryl can also have a sedative effect in cats, but Eddy cautions that it can have the opposite effect as well: Instead of calming your cat, your cat could become even more fired up, he says. Finally, you could potentially use Benadryl to prevent motion sickness in your cat before riding in the car.

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