Due to the high elevation of Masai Mara and Nairobi, Malaria is very rare in these regions since mosquitoes do not live at those elevations. However, Malaria is prevalent in other regions of Kenya, so it is strongly recommended that you speak with your physician about taking Malaria prophylaxis before traveling.

Malaria is present in the Masai Mara, but the risk is generally considered low to moderate depending on the season. Because the Mara sits at a relatively high elevation (around 5,000 to 6,000 feet), the cooler temperatures are less hospitable to the Anopheles mosquito than the Kenyan lowlands. However, the risk increases during and immediately following the rainy seasons (March–May and October–December) when standing water provides breeding grounds. In 2026, health authorities still strongly recommend that safari-goers consult a travel clinic for prophylaxis (like Malarone or Doxycycline) and use "pro" preventative measures: wear long sleeves at dusk, apply DEET-based repellent, and always sleep under the provided mosquito nets in your camp. While the chance of infection is statistically low for a short-term visitor, the potential severity of the disease makes consistent prevention an essential part of any Kenyan safari preparation.