Globally, there are an estimated 200,000 cases of yellow fever yearly, causing 30,000 deaths.
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South Africa requires a valid International Certificate of Vaccination or Prophylaxis (ICVP) documenting yellow fever vaccination =10 days before arrival in South Africa for all travelers aged =1 year, traveling from or transiting for >12 hours through the airport of a country with risk for yellow fever virus ...
About 15% of symptomatic patients will develop severe disease. Most will recover, but after a bout of yellow fever, full recovery may take weeks or months. In most cases, there is a reversal of the liver and renal dysfunction. Death occurs in 30% to 50% of patients with severe disease.
Required for travelers =1 year old arriving from countries with risk for YF virus transmission; this includes >12-hour airport transits or layovers in countries with risk for YF virus transmission. Generally not recommended for travel to Tanzania.