You can ask the driver, Will this bus take me to Main Street (or wherever you want to go)? You could also say something like, Could you please tell me when we get to the Main St.
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On the Bus. Pay your full fare to your final destination. Tell the bus driver where you are going and whether you need a transfer and/or a change card.
If the bus has a stop button, use it. Sometimes you have to pull a cord (usually around and above the windows) or press on a rubbery strip to do the same thing. Watch the other passengers and look around the bus. If there's no such device, or the bell doesn't work, speak up.
In normal speech, the preferred expression for a bus, train, plane, and other public transport vehicles would be to “get off”. Although you can say that you “take a bus” when you “get on the bus” (not “in”), you can't say that you “take off the bus” when you “get off”: correct I must get off (the bus) at the next stop.
For trains, buses, boats and planes, use “on.” You might say, for example, “I'm on the plane now. I have to turn off my phone.” For trucks, cars and helicopters, use “in.” You can say, “I'm in a taxi,” for example.
Do bus drivers like it when people say thank you? Dozens of London bus drivers who were interviewed as part of the research said passengers greeting them with 'good morning' or 'thank you' have a positive impact on their happiness and job satisfaction. They said it made them feel 'respected', 'seen' and 'appreciated'.