Whether you have hard or soft luggage, your disinfectant can be the same: hydrogen peroxide or rubbing alcohol. Reichert advises wiping down the entire suitcase with either.
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High-quality, durable luggage can last for over a decade of frequent use.
The ideal place to keep suitcases is in the bathroom or in a dry bathtub, as bed bugs are less likely to be found in these areas. You can also keep them in closets or on the luggage racks provided in most hotel rooms, but make sure to inspect these areas for signs of bed bugs before placing your luggage there.
So to repel any potential invaders, spray each part of your luggage. You don't need to spray everything inside. Spray the suitcase itself, so that the bed bugs will be repelled from the outside. If you spray your luggage, and put an impermeable plastic cover on it, you're ready to go.