Generally, covering a smoke or vape detector with a shower cap or a plastic bag will prevent it from going off because the cap prevents the smoke from reaching the chamber of the sensor.
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Well, sort of. Non-smoking hotel rooms have smoke detectors that will be set off by vaping. However, if you are determined to do it anyway, the bathroom is the best spot to avoid getting caught. They tend to have an extractor fan and tiled walls that won't trap the smell like carpets, curtains, or bedding do.
But if you get close enough to a smoke detection device, the particles from exhaled vapour will act in the same way as cigarette smoke does. The particles if directly aimed at the device will set off the alarm – whether it's ionisation detection alarms, heat-based trigger alarms or optical alarms.
Smoke detectors are an essential safety feature in hotel rooms, designed to detect the presence of smoke and alert occupants to potential fires. However, covering or tampering with these devices can have serious safety consequences.
Can airplane bathrooms detect vape? Yes. And it sets off an alarm in the cockpit and in the cabin. Most smoke detectors in aircraft lavs use an optical sensor, they see the vapor or smoke, not the heat.