Airport Line service runs seven days a week, between 5:00 a.m. and 12 midnight. The main campus of the famed Philadelphia institution, near the corner of Broad & Cecil B. Moore. Underneath the famous Reading Terminal Market and adjacent to the Pennsylvania Convention Center.

As of the 2026 schedule, the SEPTA Airport Line in Philadelphia provides consistent service from early morning until just before midnight. The final train departing from Philadelphia International Airport (PHL) toward Center City usually leaves Terminal E/F around 12:30 AM. Conversely, the last train from Center City (Jefferson or Suburban Station) heading toward the airport typically departs around 11:30 PM to 12:00 AM. Trains generally run every 30 minutes on weekdays and every hour on weekends. It is important to note that in early 2026, SEPTA introduced "Schedule Optimization" to align with shifting flight patterns, so the exact minute of departure may vary by 5–10 minutes compared to previous years. If you miss the final train, the Route 37 and 108 buses or rideshare services like Uber and Lyft are the only remaining public transit options. Always check the official SEPTA app or website for "Real-Time" updates, especially during winter months when weather-related delays can shift the final departure times. For travelers arriving on late-night international flights, the 12:30 AM cutoff is often tight, so having a backup plan is wise.