To prevent motion sickness, the first dose should be taken ½ to 1 hour before starting activity: Adults and children 12 years and over: 1 to 2 tablets every 4-6 hours; do not take more than 8 tablets in 24 hours, or as directed by a doctor.
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The name of this medication is dimenhydrinate. To prevent motion sickness, take this medication a half hour to an hour before you travel.
That said, many studies show that as a whole, Dramamine is more effective at preventing motion sickness, though it is less convenient given the dosing. Another option is scopolamine, which is commonly known as the round patch placed behind one's ear.
The problems with these drugs are the side effects, and for that reason, the FAA doesn't allow their use by flight crewmembers. The OTC antihistamines, including dimenhydrinate (Dramamine), diphenhydramine (Benadryl), and meclizine (Antivert), are capable of inducing drowsiness in some people.
As an antidote for motion sickness, most flight instructors know to advise motion-sick students to focus on a non-moving landmark in the distance, drink water, take deep breaths in through the nose, and point the air nozzle towards them.