The elimination half-life of trazodone in dogs is 120-200 minutes (2 - 3 hours). This is the time in which half of the drug is cleared from the body. Therefore, trazodone would last for approximately 6-12 hours in dogs at therapeutic doses.
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Official answer. After a single dose in a healthy adult, trazodone will be mostly out of your system in one to three days. For trazodone the half-life is approximately 5 to 13 hours. This means that every 5 to 13 hours, the level in your blood will drop by 50 percent.