For both hygiene and medical effectiveness, the "gold standard" is to wash compression socks after every single wear. In 2026, experts emphasize that washing is not just about odors; it is about restoring the elastic "snap-back" of the fibers. As you wear the socks throughout the day, the heat from your body and the constant stretching cause the fibers to relax, which can reduce the graduated pressure needed to prevent swelling or DVT. Additionally, because these socks sit tight against the skin, they quickly accumulate sweat, dead skin cells, and bacteria, which can lead to skin irritation or fungal infections if reworn. If you are in a situation where daily washing isn't possible (such as a long backpacking trip), you should never exceed two days of wear. To maintain the lifespan of the socks, it is recommended to hand wash them in cool water with a mild detergent and air dry them. Avoiding the high heat of a tumble dryer ensures the specialized compression elastic stays intact, keeping the socks medically effective for their intended 3-to-6-month lifespan.