It is best to take any form of Dramamine at least 30 minutes to an hour before any activity that causes your motion sickness. Regular Dramamine lasts about four to eight hours, whereas Dramamine Less Drowsy lasts 24 hours.
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Dimenhydrinate may cause excessive drowsiness due to its anticholinergic effects. Patients should use caution in driving or operating machinery. Patients should also avoid alcoholic beverages and other drugs known to cause CNS depression or drowsiness.
Over-the-counter medications like Dramamine, Meclizine (also known as Bonine) or diphenhydramine (commonly called Benadryl) can also help prevent or alleviate seasickness. On some ships, these are dispensed freely or are sold in the sundries shop.
Dramamine is an over-the-counter preventative drug that can help with motion sickness while flying. Although this medication can cause severe drowsiness, it can help you sleep through your flight instead of feeling the unfortunate common symptoms.