The earplugs may be re-used until they are dirty or no longer sticky (up to 5 uses). Keeping your hands and ears clean and dry prior to handling/applying the earplugs will help prolong the usable life of the earplugs.
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Sleeping with earplugs is generally safe. However, regular use does come with some potential risks. Over time, they may push earwax back into your ear canal, causing a buildup. This can cause issues like ear pressure, tinnitus and temporary hearing loss.
The length of time that it is safe to wear ear plugs depends on the type of earplugs being used, as well as the individual wearing them and the situation they are being used in. For disposable foam ear plugs that are commonly used to block out noise, it is generally safe to wear them for up to 8 hours at a time.